Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates

• Wang-Yong Yang,
• Samantha A. Marrone,
• Nalisha Minors,
• Diego A. R. Zorio and
• Igor V. Alabugin

Beilstein J. Org. Chem. 2011, 7, 813–823, doi:10.3762/bjoc.7.93

• cytotoxicity) value of 1.49 × 10−7 M. Keywords: cancer cell proliferation assay; DNA alkylation; lysine conjugate; photocycloaddition; photo-DNA cleavage; plasmid relaxation assay; triplet excitation; Introduction Triggering chemical processes with light offers numerous practical advantages. Not only does